伊卢多啉的合成
摘要
近年来，肠易激综合征一直没有专门治疗的特效药，一直困扰着全球的很多患者，本文简介了Eluxadoline，在医药领域有重要的意义，是针对腹泻型肠易激综合征的一种特效药物，Eluxadoline是一种口服mu;-阿片受体激动剂和delta;-阿片受体拮抗剂,有强大的止泻剂、镇痛活性。医药前景广大，市场需求很大，研究意义非凡，并详细介绍了伊卢多啉及其中间体1的合成路线，合成路线复杂，中间产物较多，反应包括取代，水解，氧化还原等反应类型，反应需要大量不同的催化剂，氧化剂，还原剂等。同时介绍了工业合成伊卢多啉的的步骤方法。以及对铲平的检测。
关键词：发展；前景；合成；制备，检测
The synthesis of Eluxadoline isomeride
ABSTRACT
Irritable bowel syndrome in recent years, there has been no specific, special treatment has been plagued by many patients around the world, this paper introduced the Eluxadoline, has an important significance in the field of medicine, against diarrhea type irritable bowel syndrome is a kind of special drug, Eluxadoline is an oral mu opioid agonist and delta - opioid receptor antagonist, has a strong antidiarrheal agent and analgesic activity. Pharmaceutical prospects for the market demand is very big, research significance, and introduces in detail the yi lu Lin and its intermediates 1 synthetic route, complex synthetic route and intermediate, including substitution, hydrolysis, oxidation reduction reaction type, such as reaction requires a lot of different catalyst, oxidant, reductant, etc. At the same time introduces the industrial synthesis of yi lu Lin the steps of the method. And about the detection of leveling.
Key words:development; Prospects; Synthesis; preparation;detection
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